- Antibody type:Primary
- Antigen name:Interleukin 6
- Antigen symbol:IL6
- Clonality:Monoclonal
- Clone:1.2-2B11-2G10
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- Isotype:
- Reactivity:Human
- Western blot:Yes
- Environmentally Preferable:
- Form:Lyophilized
- Gene ID:3569
- Antigen synonyms:HSF|HGF|IFNB2|interferon beta 2|BSF2|IL-6
- Storage temperature:Stable at room temperature for at least one month and for greater than a year when kept at –20 °C. Reconstitute in sterile water to a concentration of 0.1 - 1.0 mg/mL. Stable for at least six weeks at 2-4 °C when reconstituted.
- Shipping temperature:RT
- Immunogen:The monoclonal antibody was produced in BALB/c x C57BL/6 F1 mice using recombinant hIL-6 as the immunizing antigen.
- Size:500 µg
- Pk:500 µG
IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. In addition, IL-6 appears to interact with IL2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.
Type: Primary
Antigen: IL6
Clonality: Monoclonal
Clone: 1.2-2B11-2G10
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human