APLIA7682

Supplier: PanReac AppliChem
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A7682.0005EA 161 GBP
A7682.0005
APLIA7682
Apramycin is a aminocyclitol antibiotic and component of the nebramycin complex of Streptomyces tenebrarius. It is similar to the aminoglycoside antibiotics, but differs that much that it is not inactivated by aminoglycoside-inactivating enzymes. Apramycin is a strong inhibitor of the bacterial protein synthesis.

Apramycin inhibits the translocation step in protein synthesis and leads to translation errors. Therefore, Apramycin interacts with the A-site-specific bases of the 16S rRNA. Under normal conditions, tRNA-molecules would bind at this site.

In practice, Apramycin sulfate is used as a selection marker in cloning. The working concentration is 25 or 50 μg/ml. Stock solutions of the water soluble substance are prepared as 1 mg/ml to 50 mg/ml and stored at –20°C.
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