L(+)-Histidine monohydrochloride monohydrate, white powder

Supplier: MP Biomedicals
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Synonyms: H-His-OH.HCl.H2OL-Histidine monohydrochloride monohydrate(S)-(+)-Histidine monohydrochloride monohydrateHis HCl monohydrate(2S)-(+)-Histidine monohydrochloride monohydrateL-Histidine hydrochloride monohydrateL-3-Imidazol-4-ylalanine monohydrochloride monohydrate

ICNA0210195790EA 385 GBP
ICNA0210195790 ICNA0210195725 ICNA0210195791 ICNA0210195780
L(+)-Histidine monohydrochloride monohydrate, white powder
L(+)-Histidine monohydrochloride monohydrate

L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. Exogenous histidine has been shown to enhance the biosynthesis of lovastatin by cultured Aspergillus terreus. Histidine has been utilised as a single nitrogen source to probe swarming in Pseudomonas aeruginosa on agar. An in vivo study has used L-histidine to diminish the net secretory response of the small intestine of of cholera toxin-challenged mice.

Because the pKa of the imidazole group is close to physiological pH, the imidazole moiety can be either uncharged or positively charged, depending on the local environment. This property makes histidine residues of exceptional interest in the active sites of many proteins, such as hemoglobin and myoglobin, where the imidazole ring can readily alternate between the charged (imidazolium) and uncharged (imidazole) states to participate in bond formation and breakage. Histidine is biosynthesised from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. In turn, histidine is degraded to glutamate by histidase, urocanase, and imidazolonepropionase via the formation of urocanate, 4-imidazolone 5-propionate, and N-formiminoglutamate.

Soluble in water (50 mg/ml); insoluble in diethyl ether, methanol and alcohol.

Caution: Research Use Only (RUO).

Formula: C₆H₉N₃O₂·HCl·H₂O
MW: 209.63 g/mol
Storage Temperature: Ambient
MDL Number: MFCD00151027
CAS Number: 5934-29-2

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Specification Test Results

Identity Test Passes
FTIR Conforms to Standard
pH (2% aq soln) 3 - 5
Loss on Drying (145 - 150°C, 3 hour) 7 - 10%
Optical Rotation +9,5° ± 1° (c = 1, 6 N HCl)
pka 1,80 (COOH); 9,33 (NH2); 6,04 (imidazole group) (Lit.)
Isoelectric Point 7,641(Lit.)

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