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Merck for the pharmaceutical industry

Merck for the pharmaceutical industry

You love Merck chemicals but you are having difficulties finding the right product for your pharmaceutical application? Look no further!
Merck has developed this campaign for the pharmaceutical industry to give you an overview of all possibilities for your applications. 

From the famous acetonitrile 1.00030.2500 to the Merck Millipore Milli Q systems for the lab water you need. Discover a selection of solvents, acids, bases, ICP standards, water systems, etc. 
Everything you need for your chromatography, air sampling and environmental analysis, quality control, sample preparation, water determination, element analysis, etc.  



Ascentis® Express UHPLC and HPLC columns

The Fused-Core® technology behind our Ascentis® Express columns delivers maximum speed and efficiency on both UHPLC and HPLC systems. Fused-Core® particles provide a much shorter diffusion path compared to totally porous particles, minimizing peak broadening. This result in very high efficiencies, which are typically 40% higher in comparison to fully porous particles of the same size. Ascentis® Express column are available with 2, 2.7 and 5μm particles and with a very broad range of column chemistries.

Ascentis® Express columns

BIOshell™ UHPLC and HPLC columns

BIOshell™ UHPLC and HPLC columns deliver maximum speed and efficiency for the separation of biomolecules on both UHPLC and HPLC systems. The Fused-CoreR superficially porous silica particles (SPP) with pore sizes from 90 A up to 1000 A allows superior separation of glycans as well as very large proteins. In particular, a pore size of 1000 A shows very clear advantages over common 300 A pores for the separation of very large proteins in biotherapeutic drug development such as monoclonal antibodies (mAbs) or proteins with molecular weights greater than 100 kDa.

BIOshell™ columns

Purospher® STAR HPLC and UHPLC columns

Analytical methods for pharmaceutical samples have to follow strong regulations. PurospherR STAR RP-18 endcapped columns are perfectly suitable for this demand and are the best choice for L1 columns listed in the USP (United States Pharmacopeia).

Purospher® STAR columns

GC columns

Merck knows that only the most accurate analytical products will do. That’s why we offer the Supelco portfolio of analytical GC columns, providing you the accuracy, precision and consistency you need.

Supelco® GC columns

Chromolith® WP300 columns for bio applications

The new Chromolith® WP300 columns are designed specifically for bio applications. Wide pore (WP) 300A monolithic silica columns are made of a single continuous bed- rod of high purity porous silica that is then bonded with C18, C8 and C4. Protein benefits of preparative columns:

  • High biorecovery and special selectivities for biomolecules
  • High speed separation possible
  • Substantially longer column lifetime
  • High resistance to column blockage
  • Cost savings from higher sample throughput and column durability

See Chromolith® WP300 products

Chromolith®HR columns with high resolution


Chromolith® columns are unique in the chromatography business. They consist of a single rod of high purity monolithic silica. The result is a unique bi-modal pore structure which leads to greatly improved chromatographic performance in terms of separation efficiency and column back pressure.

See Chromolith® HR products

LiChrosolv® solvents

LiChrosolv® solvents are ideal for reproducible separations.
Benefits of LiChrosolv® solvents:

  • Documented as being suitable for UV, fluorescence and mass detection, as well use in UHPLC
  • Optimised peak baseline separation
  • High resolution and sensitivity
  • Interference-free baseline for better reproducibility
  • Discover, for example, acetonitrile hypergrade (MERC1.00029.2500) specifications and Certificate of Analysis

See Lichrosolv® solvents

Solvents in gas chromatography and LC-MS

The accurate analysis of residual solvents in drug substances with headspace gas chromatography and the organic trace analysis and LC-MS-based methods require very pure solvents with extremely low concentrations of the defined residual solvents.

Merck has developed specific ranges for this. Click on the range to see the full product selection.

LiChrosolv® solvents for HPLC and LC-MS

SupraSolv® solvents for GC

Quality control


Pharmaceutical Secondary Standards

Merck´s Secondary Pharmaceutical Standards are certified under double accreditation to ISO/IEC 17025 and ISO Guide 34 and are multi-traceable to reference standards from various Pharmacopeial organizations such as USP, PhEUR, and BP.

Pharmaceutical Secondary Standards

NEW UHPLC-MS LiChrosolv® solvents

For your highly sensitive UHPLC-MS analyses, how can you reduce noise and additional signals to a minimum? Merck’s new high-end UHPLC-MS solvents raise the standard for low baseline noise and clean mass spectra. The new range of advanced UHPLC-MS LiChrosolv® solvents have been developed to exceed all expectations, providing rapid and reliable results in both ESI/APCI positive and negative ionization modes.

LiChrosolv® UHPLC-MS solvents

LiChropur® additives and Lichropur® Reagents for Ion-Pair Chromatography

To help you obtain the highest quality analysis, Merck offers a wide range of high purity mobile phase additives for LC-MS applications. The LC-MS portfolio includes the most commonly used acids, bases and volatile salts of high purity tested for LC-MS applications.

LiChropur® additives and reagents

Certified Reference Materials

As the only manufacturer of analytical standards and Certified Reference Materials (CRMs) with a global presence, Merck provides the scientific community with a comprehensive portfolio and trusted brands. High quality Reference Materials are available only from organizations with a robust quality system. Double Accreditation to ISO/IEC 17025 and ISO Guide 342 represents the pinnacle of quality system achievement and allows the credible production and testing of CRMs.

Certipur® ICP standards

TraceCERT® ICHQ3D element standards

Certipur® buffer solutions

With certified pH values at both 20 °C and 25 °C, Certipur® pH buffer solutions from Supelco® analytical products meet your calibration needs. Compliance, always ensured.

Certipur® buffer solutions

MAS-100 NT® - air samplers

The MAS-100 NT® microbial air sampler is a portable instrument developed for use in critical environments. These devices are compact yet sophisticated and deliver the highest quality in microbial air monitoring. The benefits are:

  • Very easy to handle
  • Hardware and software developed according to GAMP 4
  • A flow sensor is used to measure and ensure a flow of 100 SLPM ±2,5%
  • Validated according to EN ISO 14698 Part 1 Annex B
  • Fully meets the d50 requirements using the 300x0,6 mm sampling head

See Merck air samplers            Ask for MAS 100 demo

EMSURE® acids, salts and solvents

EMSURE® acids, salts and solvents offer you:

  • Accuracy and reliability – every time
  • Convenience and safety
  • Regulatory compliance (ISO 6353, ACS, Reag. Ph. Eur.)

They are tested for up to 70 parameters in Merck’s stringent quality control lab in Darmstadt, Germany.
Discover, for example, product specifications of acetic acid, Reag. Ph. Eur. analytical reagent



The specifications include over 50 parameters, far more than the amount of parameters
required for Ph. Eur.

See EMSURE® products

Aquastar™ reliable water determination

Aquastar™ Karl Fischer reagents and standards for trusted results in your water determination. Karl Fischer titration is one of the most precise and fast method to determine water contents in a range of 10 ppm to 100%.
The Aquastar™ products standards are suitable for titer determination or instrument check and are compliant with the requirements of DIN EN ISO / IEC 17025 accreditation.

Contact your local VWR specialist to receive your application note or demo pack for method development.

See AquastarTM products

Certipur® , ICP multi-element standards

All Merck’s ICP Certipur® standards are compliant with ISO 17025 and ISO guide 34. These multi-element standards are traceable to primary standards and are supplied an extensive Certificate of Analysis.

See ICP Certipur® products



See Spectroquant® spectrophotometers



Prepsolv® solvents for preparative chromatography

Merck Prepsolv® solvents are tailored to facilitate scale-up from analytical to preparative separations and are manufactured taking into account the special requirements of preparative chromatography. They are characterized by an extremely low evaporation residue (< 1 mg/l) and low water content. The solvent quality ensures optimal product yield and column protection. The extensive range of withdrawal systems ensures the solvents can always be safely and easily used without any risk of contamination.

Prepsolv® solvents

Solvents for DNA and peptide synthesis

DNA and peptide synthesis applications demand solvents with the lowest possible water content. That’s why Merck’s solvents are carefully processed and purified to optimize efficiency and yields in these critical processes. Merck provides a growing range of specialized solvents and reagents for DNA and peptide synthesis – both on a custom basis, as well as for the broad market. The extensive range of withdrawal systems ensures solvents can be used safely and easily, without any risk of contamination.

Solvents for DNA and peptide synthesis

High quality TSB

Tryptic Soy Broth (TSB) from Merck is tested for sterility and absence of Mycoplasma. It comes in a high performing granulated format along with triple-wrapped packaging, ready for use in a cleanroom.

See the TSB selection below:

Tryptic soy broth, non animal, irradiated, triple bagged, 5kg

Tryptic soy broth, irradiated, triple bagged, 5kg

MSYNTH®plus for organic synthesis

MSYNTH®plus products are developed for organic synthesis in regulated environments in order to make qualification of starting materials as simple as possible. The range is qualified for use in GMP synthesis and is optimised for research, process development and production. The portfolio includes building blocks, reagents, solvents, process chemicals and additives.

See MSYNTH® plus products



Acids in Safebreak bottles

Safebreak bottles from Merck are made of glass with a PE coating. When the glass breaks, the splinters are caught by the PE jacket.

See Acids in Safebreak® bottles


Extran® cleaning agents are developed for use in labs and production facilities. These cleaning agents ensure residue-free, thorough cleaning. All active ingredients are biodegradable.

See Extran® products


Chemizorb® absorbants consist of porous minerals or synthetic co-polymers that are chemically inert and capable of taking 100 to 400% of their own weight in liquid material. Chemizorb® is used to remove spilled liquids quickly and safely.

See Chemizorb® products

Milli-Q® IQ7000 purification system

Milli-Q® IQ 7000 has been developed to ensure that experiments are safe from ionic contaminant traces. An ideal system for ultrapure water in combination with the new Q-POD® ultrapure water dispenser!

  • Compact and ergonomic
  • Simple and intiutive dispensing
  • Environmentally friendly UV lamp (no Hg)
  • Purification media with exceptional performance

See Milli-Q® products